The MS-06F Zaku II is one of many variants of the MS-06 Zaku II series and first appeared in Mobile Suit Gundam television series.

The MS-06F Zaku II was the Principality of Zeon's mainstay mobile suit during the One Year War. Compared to the MS-06C Zaku II Early Production Type, the MS-06F removed the heavy anti-nuclear protections, reducing its armor weight and improving its mobility. It was also refitted with a more powerful generator: the MYFG-M-ES series fusion reactor, jointly developed by Zeonic and M&Y Company. Otherwise, it was not significantly different from its predecessors, the MS-06A and the MS-06C. There existed subtle differences among the F-Type, depending on the time of manufacture and the originating factory. Prior to the introduction of the MS-06S Zaku II Commander Type, MS-06F piloted by squadron leaders were equipped with a head-mounted blade antenna.

The MS-06F could run at a speed of 85 km/h, leap 100m into the air with the use of its thrusters, and lift around 80-90t of weight with one hand. Its thrusters had a thrust of 45 tons. Though its punch had a force of 560t, doing so risked severely damaging its manipualators. Instead it more frequently used the spike armor on its left shoulder for shoulder tackle, which had a force of 4,500t. The cost of a MS-06F was equivalent to that of five Type 61 Tanks, or 1,500 civilian automobiles from the year U.C. 0078 (each costing 30% of a salaryman's average annual salary).